Chic2 gene

Author: pvkm

August undefined, 2024

WebThe target: CHIC2, gene name: CHIC2, also named as BTL. This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic … WebThe closest mouse gene, according to BlastP, is the AceView gene Chic2(e=7 10-73). The closest C.elegans gene, according to BlastP, is the AceView/WormGene 3B256(e=2 10-30) RNA_seq discoveries. Expression/conservation in primates tissues evaluated by cross-mapping to human.

CHIC2 Gene - Somatic Mutations in Cancer - Wellcome Sanger …

WebSep 7, 2024 · The FIP1L1-PDGFRA fusion gene, a constitutively activated tyrosine kinase, arises as a result of a deletion on chromosome 4q12 . The CHIC2 gene is located in this region. As such, the FIP1L1-PDGFRA fusion gene is often referred to as “CHIC2 deletion” . This is usually detected with FISH but can also be detected by RT-PCR. Web丁香通为您提供fitc标记的转录因子e商品详情介绍：价格：¥2980，货号：lm-13115r-fitc，品牌：lmai bio，详见丁香通fitc标记的转录因子e商品详情页； tractor supply jamison pa

2-Bromo-4

WebJan 1, 2024 · The t(4;12)(q12;p13) has been rarely reported in both myeloid/lymphoid neoplasms with eosinophilia (ETV6/PDGFRA gene fusion) and acute myeloid leukemia (AML) (ETV6/CHIC2 gene fusion).The ability to accurately characterize t(4;12) is critical as myeloid neoplasms with PDGFRA rearrangements may be amenable to tyrosine kinase … WebCHIC2 deletion was observed in bone marrow cells for 3 of 5 patients with SMCD associated with eosinophilia [1]. We recently cloned the CHIC2 gene (previously BTL) by virtue of its involvement in a chromosomal translocation t (4;12) (q11;p13) occurring in acute myeloid leukemias [2]. WebMar 29, 2024 · Go to Variation Viewer for CHIC2 variants; Summary. This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich … the rough york me

Pharos : Target Details - CHIC2 - National Institutes of Health

UniProt

WebThe gene view histogram is a graphical view of mutations across CHIC2. These mutations are displayed at the amino acid level across the full length of the gene by default. … WebFunctional Associations. CHIC2 has 5,675 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 67 datasets. the roundabout rockwall txWebSep 1, 2024 · Gene: CHIC2; cysteine rich hydrophobic domain 2: Aliases: BTL : Location: 4q12: Summary: This gene encodes a member of the CHIC family of proteins. The … tractor supply jasper tx

"WebDescription: Homo sapiens cysteine-rich hydrophobic domain 2 (CHIC2), mRNA. RefSeq Summary (NM_012110): This gene encodes a member of the CHIC family of proteins. … " - Chic2 gene

Chic2 gene

WebNotably, cases of acute myeloid leukemia with a CHIC2-ETV6 fusion gene have been reported indicating a possible role of CHIC2 in cancer [14]. However, its function remains largely unknown. ... http://www.informatics.jax.org/marker/MGI:1921527

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WebJan 11, 2007 · The CHIC2 gene deletion at 4q12 results in a fusion between the FIP1L1 and PDGFRA genes. As a consequence the PDGFRA tyrosine kinase is activated. Interestingly, imatinib mesylate, a tyrosine ... WebJun 1, 2009 · The PDGRFA locus has become a gene of interest based on mutational activation in various myeloid neoplasms and the availability of targeted therapies (i.e., imatinib mesylate) to its overexpression. We studied a new FISH method to detect CHIC2 deletion, FIP1L1/PDGFRA fusion and PDGFRA translocation in patients with myeloid …

WebJun 24, 2024 · 4q12; interstitial deletion of CHIC2 region) is observed in diverse eosinophiliaassociated hematologic - disorders. The cases with FIP1L1-PDGFRa fusion show an excellent response to the tyrosine kinase inhibitor imatinib mesylate (Metzgeroth et … WebA blood cancer in which the bone marrow makes abnormal myeloblasts due to t(4;12)(q12;p13) resulting in CHIC2-ETV6 gene fusion. CHIC2 is a member of a family of proteins that function in exocytosis. ETV6 is an erythroblast-transformation specific transcription factor. Research has suggested that ectopic expression of the homeobox …

WebCiGAS gene family is an interesting target to study differences in editing characteristics of different methods, because there are four members (CiGAS-S1, -S2, -S3 and -L) that share the same intron/exon structure and have similarities but also small differences in the coding sequence (Bogdanović et al., 2024). WebCHIC2 deletion, a surrogate for FIP1L1/PDGFRA fusion, occurs in systemic mastocytosis with eosinophilia and predicts response to imatinib mesylate therapy. Blood …

WebNov 6, 2024 · FIP1L1-PDGFRA is an abnormal fusion gene sequence that causes the bone marrow to produce too many eosinophils, a type of white blood cell.It is a rare cause of …

WebMar 1, 2014 · First mechanism: In-frame fusion between CHIC2 exons 1-3 and exons 2-8 of the ETV6 gene. Second mechanism: Breakpoints located in introns 1 and 2 of ETV6 but outside the CHIC2 gene, with no detectable CHIC2-ETV6 fusion gene. Fusion protein Fusion protein contains both the HLH and ETS domains of ETV6 but no specific domain … the roundabout storeWebTitle: SLC1A2 Gene Rearrangement Definition: A molecular abnormality indicating rearrangement of the SLC1A2 gene. Semantic Type: Cell or Molecular Dysfunction Semantic ID: T049 Concept ID: C5670928 ID: 1812369 9. Title: CHIC2 Gene Rearrangement Definition: A molecular abnormality indicating rearrangement of the … the roundabout restaurant racine wiWebThis gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the … the roundabout diner portsmouthWebView mouse Chic2 Chr5:75165665-75205302 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression the roundabout dinerWebFeb 1, 2002 · N term CHIC2 with the first 110 amino acids (exons 1 to 3) fused to the441 C term amino acids (exons 2 to 8) of ETV6. Bibliography. Pubmed ID Last Year Title Authors; 10477709: 1999: Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). Cools J et al: 11257495: 2001: A new family of small, palmitoylated ... the roundabouts craftWebPanel Description. Sequence variants and/or copy number variants (deletions/duplications) within the CHIC2 gene will be detected with >99% sensitivity. Variants classified as … tractor supply jesup ga 31545WebA chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6 1 publication. ... Gene name Length; D6RDW7: D6RDW7_HUMAN: CHIC2: 146: H0Y8H1: H0Y8H1_HUMAN: CHIC2: 137: Keywords. Coding sequence diversity. #Chromosomal rearrangement; Technical term. … the roundabout stop playdays