Phospho stat3
WebPhospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (Alexa Fluor ® 750 Conjugate) detects endogenous levels of Stat3 only when phosphorylated at Tyr705. This antibody does not cross-react with phospho-EGFR or the corresponding phospho-tyrosines of other Stat proteins. Species Reactivity: Human, Mouse, Rat, Monkey WebPhospho-Stat3 (Tyr705) Antibody detects endogenous levels of Stat3 only when phosphorylated at Tyr705. The antibody does not cross-react with other Stat proteins …
Phospho stat3
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WebNitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a modulator of the signal transducer and activator of transcription 3 (STAT3) activity. In our … WebPhospho-STAT3 (Ser727) Polyclonal Antibody Advanced Verification This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. 2 Published Figures 15 References View all (92) STAT3 antibodies Catalog # 44-384G 100 µL USD 453.00 Check your price & availability Join Aspire™ for free antibodies Quantity
WebThe BD CBA Phospho Stat3 (Y705) Flex Set must be used in conjunction with a BD CBA Cell Signaling Master Buffer Kit (Cat. No. 560005, 100 tests, or 560006, 500 tests) and a flow cytometer. Detailed instructions on the use of this product can be found in the manual for the BD CBA Cell Signaling Master Buffer Kit. WebApr 13, 2024 · Phosphorylated STAT3 dimers translocate to the nucleus and induce the transcription of target genes (POMC, SOCS3). SOCS3 inhibits the JAK2/STAT3 pathway by interacting with phospho-Y985 or JAK2 and acting as a feedback inhibitor of leptin signaling. PTP1B also inhibits leptin signaling through dephosphorylation of JAK2.
WebPhospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb detects endogenous levels of Stat3 only when phosphorylated at tyrosine 705. This antibody does not cross-react with phospho … WebThis DuoSet IC ELISA contains the basic components required for the development of sandwich ELISAs to measure phosphorylated human and mouse STAT3 (Y705) in cell lysates. An immobilized capture antibody specific for STAT3 binds both phosphorylated and unphosphorylated STAT3. After washing away unbound material, a biotinylated detection …
WebSTAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in …
WebPhospho-STAT3 was detected in immersion fixed IFN-alpha treated Daudi human Burkitt's lymphoma cell line using 10 µg/mL Human Phospho-STAT3 (Y705) Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4607) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red ... bituminous coated pipeWebApr 14, 2024 · The Phospho-STAT3 (Y705) Antibody contains sodium azide, which may react with lead and copper plumbing to form explosive metallic azides. Flush with large volumes of water during disposal. 2. ASSAY OVERVIEW 3 1. Seed cells in a 96 well plate. Stimulate cells with ligands. Fix, permeabilize, and block cells. bituminous coating on doorsWebNov 15, 2002 · As shown in Fig. 3,A, phospho-Stat3 is detected in the nucleus with different intensities in all three of the human prostate cancer cell lines examined. The intensity of red stain (Nova-Red) corresponds to the level of active phospho-Stat3, whereas the blue stain (hematoxylin) is the counterstain. bituminous coal used forSTAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator. Specifically, STAT3 becomes activated … See more Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family. See more Loss-of-function mutations in the STAT3 gene result in Hyperimmunoglobulin E syndrome, associated with recurrent infections as well as disordered bone and tooth development. See more • Hoey T, Grusby MJ (1999). STATs as mediators of cytokine-induced responses. Advances in Immunology. Vol. 71. pp. 145–62. See more STAT3 has been shown to interact with: • AR, • ELP2, • EP300, • EGFR, • HIF1A, • JAK1, See more • FactorBook STAT3 See more datboiisontheWebApr 11, 2024 · STAT3 is widely expressed in organs and tissues, and the phosphorylation of STAT3 motivates downstream genes related to proliferation and apoptosis, thus performing proliferation effects. A previous study has revealed that the motivation of STAT3 signaling promotes colonic mucus secretion in DSS-induced colitis in mice ( 28 ). bituminous coating for hollow metal framesWebSTAT3: Products The STAT family of transcription factors, first described as key mediators of interferon signal transduction, are now recognized as signaling factors downstream of many cytokines, growth factors, and hormones. At … dat booking strathclydeWebJul 8, 2024 · Here, we report that phospho-Tyr705 of STAT3 (pY-STAT3), not total STAT3, contributes to systemic inflammation and coagulopathy in sepsis. Methods: Cecal ligation … bituminous coating on door frames